CURRICULUM VITAE
PERSONAL DATA
Name : ADIB AbdennajiDate of Birth : April 10, 1959, Morocco
WORK EXPERIENCE
1998 : Grant from MEDIATORS DIAGNOSTIKA (AUSTRIA) carried out at the Laboratoire de Chimie Génétique, Faculté de Pharmacie, France. Supervisors : Dr J.-P. Behr and Dr Thomas Schlederrer. Investigations :
Synthesis of spermino-inosine and its incoporation at desired sites of various oligodeoxynucleotides on automated DNA synthesizer. This sperminoligodeoxynucleotides were labeled at 3' or 5' position with fluorescein or biotin and used in PCR.
10/1994-12/1996 : Grant from Rhône Poulenc (France) carried out at the Laboratoire de Chimie Génétique. Faculté de Pharmacie, France. Supervisor : Dr J.-P. Behr. Investigations:
1. Design and synthesis of oligodeoxynucleotides bearing polyamines linked to 2-amino of guanosines by pre- and post-oligomerization : new synthetic strategies of 2-fluoro-inosine and 2-polyamino-inosine.
2. Design of synthetic vectors for gene transfer based on cationic polymers : new synthetic galactosylated polyethyleneimine towards delivery to hepatocytes.05/1994-09/1994 : Postdoctoral position carried out at the Laboratoire de Chimie Génétique, Faculté de Pharmacie, France. Supervisor : Dr J.-P. Behr.
Synthesis of new cationic lipids like DOGS "TRANSFECTAM TM". This new cationic lipid systems have the same efficiency of gene transfer than DOGS (confidential report, Rhone Poulenc).
1993 : Postdoctoral position in the Hoffmann La Roche's laboratory of Neurology, Bâle (Switzerland). Synthesis of neuroleptics.
1989-1993 : Ph.D in Stereochemistry at the University Louis Pasteur (ULP) of Strasbourg (France). Asymmetric synthesis of optically pure epoxides :
1. Design and synthesis of new chiral sufonium salts in asymmetric epoxidation: the absolute configuration of chiral sulfonium has been determined by X-ray and 2D-NMR.
2. Design of new chiral thioester for synthesis of a,b-epoxyesters optically active (unpublished results).
TRAINING PERIODS
1989-1993 : Ph.D in organic chemistry at the ULP of Strasbourg (France). Asymmetric synthesis of optically pure epoxides.
1988 : Master's degree in Biochemistry : UV of Biochemistry, Organic Chemistry and Pharmacology.
PROFESSIONAL COMPETENCE
- Organic synthesis :
1. Design and synthesis of chiral products and cationic lipids.
2. Chemical modification of polymers and purification by ultrafiltration, HPLC, dialysis and size exclusion chromatography.
3. Design and synthesis of modified nucleosides and their incorporation in oligodeoxynucleotides on automated DNA synthesizer.
- Analytical methods :
HPLC, High Field NMR Spectroscopy (1H, 13C, 19F, 31P; 1D and 2D experiments), IR, UV, fluorescence, polarimetry and MS FAB/Electrospray.
PUBLICATIONS
- "A high-yield synthesis of deoxy-2-fluoroinosine and its incorporation into oligonucleotides". Abdennaji Adib, Pierre F. Potier, Ivan Huc, Svetlana Doronina and Jean-Paul Behr. Tetrahedron Lett., 1997, 38, 2989
- "In Vitro Gene Delivery to Hepatocytes with a new Galactosylated Polyethyleneimine". Maria-Antonietta Zanta, Otmane Boussif, Abdennaji Adib and Jean-Paul Behr. Bioconjugate Chem. 1997, 8, 839.
- "Synthesis of oligonucleotides containing N2-(spermine)-2'-deoxyguanosine". Abdennaji Adib, Alexei Kochkine, Pierre F. Potier, Ivan Huc, and Jean-Paul Behr. 1999. To be published.
- "A catalytic effect of ZnCl2 during DIBAL reduction of beta-ketosulfoxides". Solladié-Cavallo A., Suffert J., Adib A., Solladié G. Tetrahedron Lett., 1990, 31, 6649.
- "Chiral sulfur-reagent for preparation of optically active epoxides". Solladié-Cavallo A., Adib A. Tetrahedron, 1992, 48, 2453.
- "Axial Structure of Oxathiane Benzyl Sulfonium Perchlorate". Solladié-Cavallo A., Adib A., Schmitt M., DeCian A. Tetrahedron Asymmetry, 1992, 3, 1597.
- "Recognition of DNA Sequences by Strand Displacement with Polyamino-Oligonucleotides". Abdennaji Adib, Ivan Huc, Pierre Potier and Jean-Paul Behr. Molecular Recognition and Drug-Receptor Interactions. Salamanca (Espagne), September 1996.
- "Synthesis of oligonucleotides bearing polyamine groups and their use in specific recognition of DNA". Pierre Potier, Abdennaji ADIB, Alexei Kochkine, Ivan Huc and Jean-Paul Behr. XIIIth International Round Table, "Nucleosides, Nucleotides and Their Biological Applications''. Montpellier (France), September 1998.